Promethazine HCl Oral Resolution may well lessen seizure threshold. It should be employed with caution in folks with seizure Problems or in people who're working with concomitant remedies, like narcotics or community anesthetics, which may also impact seizure threshold.
Postmarketing circumstances of respiratory depression, which include fatalities, have been described with usage of Promethazine in pediatric people a lot less than 2 several years of age. A wide range of excess weight-centered doses of Promethazine have resulted in respiratory melancholy in these people.
Energetic and prophylactic procedure of motion sickness. Antiemetic therapy in postoperative patients.
Therapy adjunctive to meperidine or other analgesics for Charge of postoperative soreness. Sedation in both young children and Older people, and reduction of apprehension and production of light-weight rest from which the patient might be conveniently aroused.
Promethazine administered to some pregnant girl within two weeks of delivery might inhibit platelet aggregation in the new child.
Codeine and its salts are well absorbed pursuing both equally oral and parenteral administration. Codeine is about two/three as effective orally as parenterally. Codeine is metabolized mainly while in the liver by enzymes with the endoplasmic reticulum, where it undergoes O-demethylation, N-demethylation, and partial conjugation with glucuronic acid.
Unresponsive Cough The dosage of Promethazine HCl and Codeine Phosphate Oral Remedy should not be amplified if cough fails to reply; an unresponsive cough needs to be reevaluated in 5 times or quicker for feasible fundamental pathology, for instance international here entire body or lower respiratory tract ailment [see Dosage and Administration (2.three)].
Promethazine HCl and Codeine Phosphate Oral Solution is indicated for your momentary aid of coughs and higher respiratory symptoms linked to allergy or perhaps the popular chilly in patients eighteen years of age and older.
Some medicines may perhaps affect how promethazine works or promethazine may have an affect on how your other medicines perform. Know the medicines you take. Continue to keep a listing of them along with you to show your healthcare Skilled. Particularly convey to your healthcare Experienced if you're taking:
It is actually hard to identify what constitutes a standard toxic or lethal dose. Even so, the lethal oral dose of codeine within an Grownup is claimed to become in the number of 0.
Postmarketing scenarios of respiratory despair, which include fatalities, happen to be noted with usage of promethazine hydrochloride in pediatric people under 2 decades of age. A wide range of pounds-centered doses of promethazine hydrochloride have resulted in respiratory despair in these sufferers.
In Ladies with standard codeine metabolism (regular CYP2D6 action), the level of codeine secreted into human milk is lower and dose-dependent. There is not any information on the results with the codeine on milk creation.
Promethazine HCl Oral Remedy really should be applied for the duration of pregnancy provided that the potential gain justifies the probable danger into the fetus.
On the other hand, codeine have to be administered only beneath close supervision to clients that has a record of drug abuse or dependence.